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Home Products DCC-2036 DCC-2036 Synonyms: CAS NO: 1020172-07-9 Molecular Formula: C30H28FN7O3 Molecular Weight: 553.59 Purity: 98% min Package: 1G/BAG 5G/BAG,LAB PRODUCTS Storage: −20°C Order Order Infomation Remarks: DCC-2036 is an ABL switch control inhibitor with IC50 of 0.8 and 2 nM for u-ABL1native and p-ABL1native, respectively. DCC-2036 strongly prevents both unphosphorylated and phosphorylated ABL1 by inducing a type II inactive conformation, and retains efficacy against the majority of clinically relevant CML-resistance mutants, including T315I. DCC-2036 suppresses BCR-ABL1(T315I)-expressing cell lines, prolongs survival in mouse models of T315I mutant CML and B-lymphoblastic leukemia, and inhibits primary patient leukemia cells expressing T315I in vitro and in vivo, supporting its clinical development in TKI-resistant Ph(+) leukemia. In addition, DCC-2036 also inhibits other kinases with IC50 of 2,4,6,34,29 and 38 nM for Flt3, KDR, Tie2, Src, LYN and FGR kinases, respectively. Quality Control Quality Control by H-NMR,C-NMR,LC-MS,HPLC. 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