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Home Products PLX-4032 PLX-4032 Synonyms: RG7204 Vemurafenib RO5185426 CAS NO: 1029872-54-5 Molecular Formula: C23H18ClF2N3O3S Molecular Weight: 489.92 Purity: 99% Package: lg/bag 5g/bag labs product Storage: -20°C Order Order Infomation Remarks: PLX4032 is a highly selective inhibitor of BRAF kinase activity, with an IC50 of 44 nmol/L against V600E-mutant BRAF. [1] BRAFV600E cancer-causing mutation occurs in most melanomas and about eight percent of all solid tumors. [2] BRAF mutant melanoma cell strains were highly sensitive to PLX4032 with IC50 in the nM range (60�C450 nM), whereas BRAF wild-type cells were resistant, with IC50 2.4 ��M or above. Quality Control Quality Control by H-NMR,C-NMR,LC-MS,HPLC. Related Products Tinib Series Axitinib Amuvatinib MP-470 BIBW2992 Bafetinib Brivanib Bosutinib Cediranib Canertinib Cabozantinib Crizotinib dovitinib lactate Dasatinib Erlotinib hydrochloride E7080 lenvatinib Foretinib Fostamatinib disodium Gefitinib INCB 018424 Ruxolitinib Lapatinib Linifanib abt869 Linsitinib OSI-906 Lonafarnib Lapatinib ditosylate Motesanib Motesanib diphosphate Masitinib Mubritinib Neratinib Nilotinib Olaparib PLX-4032 Pelitinib Pazopanib hydrochloride Pazopanib Ponatinib Quizartinib AC-220 Regorafenib Sunitinib malate Sorafenib tosylate Saracatinib Tipifarnib (Zarnestra) Tandutinib Tivozanib Volasertib Vandetanib   None of the products will be supplied to countries in which this could be in conflict with the existing patents. However the final responsibility lies with the Buyer.

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