Homepage About Us Products News&Events Custom Synthesis Order Infomation Contact Us

Home Products Vinflunine Vinflunine Synonyms: Javlor CAS NO: 162652-95-1 Molecular Formula: C45H54F2N4O8 Molecular Weight: 816.93 Purity: 99% Package: 1g/bag 5g/bag ,labs product. Storage: −20°C 2 years Order Order Infomation Remarks: Vinflunine exerts marked cytotoxicity against a selected panel of nine human solid tumor cell lines of different origins (colon, prostate, bladder, breast, and ovary) with IC50 values ranging from 27 nmol/L to 14 umol/L. [1]Vinflunine, at the lowest effective concentrations, interacts with the Vinca alkaloid binding site on tubulin, suppresses microtubule dynamics (switching at microtubule ends between phases of slow growth and rapid shortening) and microtubule treadmilling (growth at the plus end and shortening at the minus end of the microtubule), causes cell cycle arrest which appears on fluorescence-activated cell sorting analysis as a G2 + M phase arrest, and is associated with an accumulation of cells in mitosis[2] leading to cell death via apoptosis.[3] In vitro vinflunine cytotoxicity proved dependent on concentration and exposure duration, with IC50 values (72-hr exposures) generally ranging from 60-300 nM. Vinflunine induced G2 + M arrest, associated with mitotic accumulation and a concentration-dependent reduction of the microtubular network of interphase cells, accompanied by paracrystal formation. Quality Control Quality Control by H-NMR,C-NMR,LC-MS,HPLC. Related Products Antineoplastic 5-Fluorouracil 6-Thioguanine 6-Mercaptopurine Azathioprine Amrubicin Hydrochloride Altretamine Aminopterinum Amiodarone hydrochloride Ancitabine hydrochloride Busulfan bendamustine hydrochloride Bleomycin sulfate Bicalutamide Bortezomib Calcium folinate CPI-613 Cytarabini Hydrochloridum Cyclophosphamide monohydrate Capecitabine Clofarabine Chlorambucil Carmustin Camptothecin Chlormethine Catharanthine Cyclopropanesulfonamide Dacarbazine Daunorubicin hydrochloride Doxorubicin hydrochloride Decitabine Epothilone B Epirubicin hydrochloride Everolimus Flavopiridol Fotemustine Fludarabine Fulvestrant Hydroxycamptothecin Hydroxyurea Irinotecan Idarubicin hydrochloride Idarubicin Lenalidomide Lomustine Methotrexate Mitoguazone Nelarabine Nimustine hydrochloride Plerixafor hcl Pixantrone Maleate Propyliminum Paclitaxel Procarbazine hydrochloride Pixantrone Pirarubicin Plerixafor Temozolomide Thio-TEPA TAK-700 Uramustine Vincristine sulfate Vinorelbine tartrate Vinblastine sulfate Vinflunine Vinpocetine Vindesine sulfate Vorinostat   None of the products will be supplied to countries in which this could be in conflict with the existing patents. However the final responsibility lies with the Buyer.

	Homepage | About Us | Products | News&Events | Custom Synthesis | Order Infomation | Contact Us Friendly link: LookChem   Copyright © Taizhou Crene Biotechnology Co.,Ltd.　技术支持：趋势科技