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Home Products Neratinib Neratinib Synonyms: HKI-272 CAS NO: 698387-09-6 Molecular Formula: C30H29ClN6O3 Molecular Weight: 557.04 Purity: 99% Package: 1g/bag 5g/bag,labs product. Storage: Order Order Infomation Remarks: Neratinib is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively.[1] Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells. Quality Control Quality Control by H-NMR,C-NMR,LC-MS,HPLC. Related Products Tinib Series Axitinib Amuvatinib MP-470 BIBW2992 Bafetinib Brivanib Bosutinib Cediranib Canertinib Cabozantinib Crizotinib dovitinib lactate Dasatinib Erlotinib hydrochloride E7080 lenvatinib Foretinib Fostamatinib disodium Gefitinib INCB 018424 Ruxolitinib Lapatinib Linifanib abt869 Linsitinib OSI-906 Lonafarnib Lapatinib ditosylate Motesanib Motesanib diphosphate Masitinib Mubritinib Neratinib Nilotinib Olaparib PLX-4032 Pelitinib Pazopanib hydrochloride Pazopanib Ponatinib Quizartinib AC-220 Regorafenib Sunitinib malate Sorafenib tosylate Saracatinib Tipifarnib (Zarnestra) Tandutinib Tivozanib Volasertib Vandetanib   None of the products will be supplied to countries in which this could be in conflict with the existing patents. However the final responsibility lies with the Buyer.

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