Home Products MK-5108 (VX-689)
MK-5108 (VX-689)
Synonyms: MK-5108 (VX-689)
CAS NO: 1010085-13-8
Molecular Formula: C22H21ClFN3O3S
Molecular Weight: 461.94
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: MK-5108 inhibits Aurora-A activity in an ATP-competitive manner. MK-5108 shows robust selectivity against the other family kinases Aurora-B (220-fold) and Aurora-C (190-fold) in the biochemical assay. MK-5108 also reveals high selectivity for Aurora-A over other protein kinases. MK-5108 inhibits only one kinase (TrkA) with <100-fold selectivity. MK-5108 may be more Aurora-A selective than MLN8054. Consistent with the induction of pHH3-positive cells, MK-5108 induces accumulation of cells in the G2-M phase. MK-5108 inhibits the proliferation of tumor cells including HCC1143, AU565, MCF-7, HCC1806 and CAL85-1 with an IC50 of 0.42 M, 0.45 M, 0.52 M, 0.56M and 0.74 M, respectively.

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