Homepage About Us Products News&Events Custom Synthesis Order Infomation Contact Us

Home Products MCOPPB trihydrochloride MCOPPB trihydrochloride Synonyms: CAS NO: 1028969-49-4 Molecular Formula: C26H40N4.3HCl Molecular Weight: 518.01 Purity: 98% min Package: lg/bag 5g/bag labs product Storage: −20°C in stock Order Order Infomation Remarks: MCOPPB trihydrochloride is a trihydrochloride form of MCOPPB that is a new nonpeptide nociceptin/orphanin FQ peptide (NOP)-receptor agonist with a pKi of 10.07 �� 0.01 for the human NOP receptor. MCOPPB exhibits anxiolytic effects with no effect on memory or locomotion. MCOPPB was regarded as one of the most potent, non-peptide NOP full agonists in vitro. MCOPPB has a high affinity for the human NOP receptor. MCOPPB has a high selectivity for the NOP receptor over other members of the opioid receptor family: 12-, 270- and >1000-fold more selective for the NOP receptor than for the micro-, kappa-, and delta-receptor, respectively. In an ex vivo binding study, MCOPPB (10 mg/kg, p.o.) inhibited signaling through the NOP receptor in the mouse brain, suggesting that MCOPPB penetrated into the brain after MCOPPB was orally administered. In the mouse Vogel conflict test, MCOPPB (10 mg/kg, p.o.) and diazepam (3 mg/kg, p.o.) elicited anxiolytic-like effects, although MCOPPB produced a bell-shaped response curve. MCOPPB at an oral dose of 10 mg/kg did not affect locomotor activity or memory, nor did MCOPPB contribute to ethanol-induced hypnosis. Quality Control Quality Control by H-NMR,C-NMR,LC-MS,HPLC. Related Products Others (S)-tert-butyl 3-oxo-1-phenylpropylcarbamate (R,R)-(-)-1,2-BIS[(O-METHOXYPHENYL)(PHENYL)PHOSPHINO]ETHANE(1,5-CYCLOOCTADIENE)RHODIUM (I) TETRAFLUOROBORATE (2R,3S)-3-(tert-Butoxycarbonyl)amino-1,2-epoxy-4-phenylbutane (1R,3s,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile (R)-Lansoprazole (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine 1095382-05-0 1-Piperidinepropanol,a,a-diphenyl-,1-methanesulfonate 1-(4,5-Diamino-10-aza-tricyclo[6.3.1.0]dodeca-2,4,6-trien-10-yl)-2,2,2-trifluoro-ethanone 3-BROMO-5-(2-PYRROLIDINYL)PYRIDINE 4SC-201(resminostat,BYK408740) 4-Amino-2-bromopyridine 518-34-3 7-Dehydrocholesterol A 769662 Almotriptan ABT-263 AZD8055 AZD 1480 AR-42 ADL-5859 Andarine AZ 3146 Argatroban AG 490 Azatadinemaleate Agomelatine AS-252424 AS-605240 Alovudine AZ 960 AS-604850 Abiraterone Acetate AZ 23 ARRY-543 ARRY380 alpha,alpha-Diphenyl-4-piperidinomethanol AZD8931 abiraterone Anacetrapib A66 Atomoxetine hydrochloride Ambrisentan AT13387 Allopurinol AZD7762 Aprepitant Blonanserin BIX 02188 BMS-946815 BIX 02189 BMS777607 Belinostat (PXD101) Bosentan hydrate Brinzolamide BMS 794833 BAN ORL 24 BMS-599626 BMS-903710 BMS-790052 BI 2536 BIBR-953 BIBF-1120 Benzbromarone CUDC-101 Canagliflozin CHIR99021 Cilomilast CCT128930 CYC116 Cefoxitin sodium CP 690550 Cidofovir hydrate Cidofovir Cyclopamine Calcitriol CX-4945 CAL-101 Ciprofibrate Cyt387 cetilistat Clemastine Fumarate CK1827452 cis-Jasmone Cerivastatin Cerivastatin sodium CH 5424802 CX-5461 CAY10505 Clopidogrel bisulfate Ceftibuten dihydrate Chlorine e6 Crenolanib CHIR-265 or RAF265 DCC-2036 DMXAA DAPT Doripenem hydrate Dabigatran etexilate Dorzolomide hydrochloride Darifenacin hydrobromide Dapagliflozin Dapoxetine hydrochloride Danoprevir Doramapimod Dalcetrapib/JTT705 Enzastaurin Eflornithine HCl Ethyliminum EX 527 Fondaparinux sodium Fenticonazole nitrate FG-4592 GW788388 Gabapentin hydrochloride GDC-0449 Vismodegib Ganetespib GSK 1120212 Gemfibrozil GSK 2126458 GSK1349572 GW 501516 Gestodene GSK 690693 GSK256066 GDC-0879 GDC0941 GDC-0980 GSK1904529A GW 843682X H-89 dihydrochloride HMN-214 ICG-001 IC-87114 Ivabradine hydrochloride INNO-206 JNJ7706621 JNJ 38877605 KU-55933 Ki16425 ku0063794 KU-60019 KN-62 LY2603618,IC-83 LY2157299 LDN193189 Lacosamide Laninamivir LY335979 LY315920(Varespladib) Liranaftate Lornoxicam LY2811376 LY2228820 MK-2206 MDV3100 MGCD-265 Melanotan II Moxidectin MRS 2578 MK-0524 Milbemycin oxime MG-132 MK-8245 MGCD0103 (Mocetinostat) Minodronic acid MK-0752 MCOPPB trihydrochloride MRE-269 Mildronate MK-1775 Merck-5 NVP-BGJ398 NVP-AEW 541 NVP-BHG712 NVP-BGT226 Nitrocaphanum NVP-LDE225 NVP-TAE684 NVP-BEZ 235 NU7441 NVP-BKM-120 OSI-027 Olopatadine Ozagrel Ostarine osi-420 Org 27569 OSU-03012 PD 0325901 Pimecrolimus Prucalopride PD 184352 Prucalopride Succinate PLX 4720 PP242 PIK-90 PD98059 PF-04971729 PI-103 PNU120596 PF-04217903 PH 797804 PF03716556 Panobinostat PF-00562271 PKI-587 PF3845 PD0332991 PX-478 dihydrochloride PF299804 PF-04929113 PCI-32765 PF-562271 Perifosine PF-00299804 dacomitinib PD173074 RO4929097 Rilpivirine RU-58841 Rebamipide R406 Roscovitine Ramelteon Rotigotine hydrochloride S31-201 (NSC 74859) SB 271046 hydrochloride SRT1720 Solifenacin succinate SRT3109 Sofalcone SCH727965 SNS-032 Sodium ceftiofur SB 203580,RWJ 64809,PB 203580 SNX-2112 SB939 SB-737050-A SU11272 SU5402 SU11274 Silodosin SB590885 Sitaxsentan sodium Selumetinib Telaprevir TG100-115 TOK-001 Tivantinib ARQ-197 Ticagrelor Torin 2 Thiazovivin Torasemide Triciribine TSU-68 TAME Tozasertib Tolvaptan TG101209 Topotecan hydrochloride TG 101348 TAK-901 Torin 1 tert-butyl 4-((5R,7S)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate Ubenimex URB597 U0126 UK 383367 Vindoline VX-765 VX 222 Vildagliptin Veliparib VX702 VX-809 WZ4002 WAY-100635 maleate salt WYE 125132 WP1130 XL 147 Y27632 Zaltoprofen Zibotentan ZM 241385 [1-(5-Fluoropentyl)-1H-indol-3-yl]-1-naphthalenylmethanone   None of the products will be supplied to countries in which this could be in conflict with the existing patents. However the final responsibility lies with the Buyer.

	Homepage | About Us | Products | News&Events | Custom Synthesis | Order Infomation | Contact Us Friendly link: LookChem   Copyright © Taizhou Crene Biotechnology Co.,Ltd.　技术支持：趋势科技