Home Products WYE 125132
WYE 125132
Synonyms: WYE132
CAS NO: 1144068-46-1
Molecular Formula: C27H33N7O4
Molecular Weight: 519.60
Purity: 98% min
Solubility: In DMSO
Storage: -20
Availability and Price
If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.
Order       Order Infomation
Shipping and handling fee USD40
Free delivery is qualified when the total value of your order exceeds 500USD
Remarks: WYE-125132 is a highly potent, ATP-competitive and specific mTOR kinase inhibitor with an IC50 of 0.19 nM. WYE-125132 blocked the activity of the both of mTORC1 and mTORC2 in various models of cancer in vitro and in vivo. WYE-125132 is 5,000-fold more selective than PI3Ks. Moreover, WYE-125132 completely blocked amino acid-induced phosphorylation of Maf1, just as S6K1, and 4E-BP1 via the inhibition of mTOR. WYE-132-treated MG63 markedly upregulated the Maf1 amouts in the nucleus. WYE-125132 showed a substantially more effective inhibition in many respects, including cancer cell growth and survival, protein synthesis bioenergetic metabolism, and adaptation to hypoxia by contrast with the rapalog temsirolimus/CCI-779.

Quality Control

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
Related Products
mTOR Inhibitors
 

None of the products will be supplied to countries in which this could be in conflict with the existing patents. However the final responsibility lies with the Buyer.

Our products are for research use only, not for human use.
 
Homepage | About Us | Products | News&Events | Custom Synthesis | Order Infomation | Contact Us
Friendly link: molbase   Copyright © Taizhou Crene Biotechnology Co.,Ltd. 技术支持:趋势科技