Home Products EX 527
EX 527
CAS NO: 49843-98-3
Molecular Formula: C13H13ClN2O
Molecular Weight: 248.71
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
Availability and Price
50MG/$250 In-stock If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.
100MG/$400 In-stock
200MG/$700 In-stock Order       Order Infomation
500MG/$1300 In-stock
Shipping and handling fee USD40
Free delivery is qualified when the total value of your order exceeds 500USD
Remarks: EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 38 nM. It is Selective inhibitor of SIRT1 that does not class I/II inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). It was thought to block the release of deacetylated peptide and O-acetyl-ADP-ribose from the enzyme following the deacetylation process. EX 527 has been used a powerful tool for studying the relationship between SIRT1 and cell regulation. Blocking of SIRT1 by EX 527 also demonstrated that deacetylation of the important tumor suppressor protein p53 is mediated by SIRT1 as well.

Quality Control

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
Related Products
Sirtuin Inhibitors and Activators

None of the products will be supplied to countries in which this could be in conflict with the existing patents. However the final responsibility lies with the Buyer.

Our products are for research use only, not for human use.
Homepage | About Us | Products | News&Events | Custom Synthesis | Order Infomation | Contact Us
Friendly link: molbase   Copyright © Taizhou Crene Biotechnology Co.,Ltd. 技术支持:趋势科技