Home Products GDC-0449 Vismodegib
GDC-0449 Vismodegib
Synonyms: GDC-0449 Vismodegib
CAS NO: 879085-55-9
Molecular Formula: C19H14Cl2N2O3S
Molecular Weight: 421.30
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. It targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO. It inhibits the growth of primary pancreatic xenografts without non-specifically inhibiting pancreatic cell proliferation in vitro and has recently entered the clinic. It also inhibits ABCG2, Pgp, and MRP1-important ABC transporters associated with MDR. The IC50 values of GDC-0449 (Vismodegib) for inhibition of ABCG2 and Pgp were about1.4 and 3.0 M, respectively. It has been used to treat medulloblastoma in animal models.

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