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   CAS NO.    Products Name
   1002304-34-8 AMG 208  more...
   AMG 208 is a selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 208 inhibits the ligand-dependent and ligand-inde...
   913376-83-7 AMG 458  more...
   AMG 458 also inhibits HGF-mediated c-Met phosphorylation in PC3 and CT26 cells with IC50 of 60 and 120 nM.AMG 458 is observed to bind covalently to liver microsomal proteins from rats a...
   850879-09-3 Amuvatinib MP-470  more...
   MP-470 is a multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Met, c-Kit, PDGFRalpha, Flt3, and c-Ret and with an IC50 of median 5 μM. MP-470 reduced c-Met ...
   1025720-94-8 BMS777607  more...
   BMS 777607 is a Small-Molecule Met Kinase Inhibitor with an IC50 of < 0.1 μM. Its treatment had little effect on tumor cell growth but inhibited cell scattering activated by exogenous...
   849217-64-7 Foretinib  more...
   Foretinib(GSK1363089, XL880) is a novel MET and VEGFR2/KDR kinases inhibitor with an IC50 of 0.4 and 0.8 nM for MET and KDR, respectively. Foretinib(GSK1363089, XL880) inhibits HGF rece...
   943540-75-8 JNJ 38877605  more...
   JNJ-38877605 is an orally bioavailable, highly specific MET inhibitor (selective over other 229 kinases tested). This agent inhibits c-MET and Phospho-MET with IC50 at 4 nmol/L and 50 n...
   875337-44-3 MGCD-265  more...
   MGCD265 is a tyrosine kinase inhibitor that targets the MET, VEGFR-1, VEGFR-2, VEGFR-3, RON and TIE2 receptor tyrosine kinases, which appear to play key roles in tumour development and ...
   1185763-69-2 NVP-BVU972  more...
   NVP-BVU972 potently inhibits MET kinase but displays low inhibition against other kinases including the most closely related kinase RON with IC50 values of more than 1000 nM. NVP-BVU972...
   477575-56-7 PHA 665752  more...
   PHA-665752 significantly inhibits c-Met kinase activity with Ki of 4 nM, and exhibits >50-fold selectivity for c-Met compared with various tyrosine and serine-threonine kinases. PHA-665...
   956905-27-4 PF-04217903  more...
   PF-04217903 is an orally bioavailabe, small-molecule MET tyrosine kinase inhibitor with potential antineoplastic activity. PF-04217903 demonstrates exquisite kinase selectivity. Inhibit...

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