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   CAS NO.    Products Name
   602306-29-6 AZD 5438  more...
   AZD5438 a potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor with IC50 of 16, 6 and 20 nM, respectively. AZD5438 exhibits antiproliferative activity in human tumor cell lines. AZ...
   582315-72-8 BMS-265246  more...
   BMS265246 inhibits the activity of CDK4/cycD with IC50 of 0.23 μM and prevents A2780 Cytox with IC50 of 0.76 μM. BMS265246 which binds to CDK2 shows the inhibitor resides coincident wit...
   146426-40-6 Flavopiridol (Alvocidib)  more...
   Flavopiridol is a Phase 3 clinical trials in high anticancer drugs, can be used for the treatment of chronic lymphocytic leukemia....
   443797-96-4 JNJ7706621  more...
   JNJ-7706621 also shows some inhibition to VEGF-R2, FGF-R2, and GSK3β, with IC50 of 154–254 nM. JNJ-7706621 shows inhibitory effect on a panel of human cancer cell types, including HeLa,...
   1231930-82-7 LY2835219  more...
   Chemical Name:2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-, methanesulfonate (1:1)...
   827022-32-2 PD 0332991 HCl  more...
   PD 0332991 has little effect on other protein kinases including EGFR, FGFR, PGFR, IR. PD 0332991 is a non-ATP competitive inhibitor of Cdk4. PD 0332991 inhibits MDA-MB-435 breast carcin...
    P276-00  more...
   P276-00 is a flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. P276-00 selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9...
   741713-40-6 R-547  more...
   R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases with a Ki of median 2 nM for CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclin D1. In vivo, R...
   186692-46-6 Roscovitine  more...
   Biological Activity of Roscovitine (Seliciclib): Roscovitine (Seliciclib) is a potent and selective inhibitor of cyclin-dependent kinases (cdks). This agent displays higher inhibitory ...
   345627-80-7 SNS-032 (BMS-387032)  more...
   SNS-032 has low sensitivity to CDK1 and CDK4 with IC50 of 480 nM and 925 nM, respectively. SNS-032 effectively kills chronic lymphocytic leukemia cells in vitro regardless of prognostic...

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