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   CAS NO.    Products Name
   878739-06-1 AZ-628  more...
   AZ628 is a potent tyrosine protein inhibitor for wild-type CRAF and BRAF V600E with IC50 of 29 and 34 nM, respectively. AZ628 inhibits activities of preactivated wild-type B-Raf with an...
   927880-90-8 CHIR-265 or RAF265  more...
   RAF265 (CHIR-265) is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. RAF is a key component of the RAS/RAF/MEK/ERK si...
   905281-76-7 GDC-0879  more...
   GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E...
   940310-85-0 NVP-BHG712  more...
   NVP-BHG712 is a small molecule specific EphB4, VEGFR2, c-raf, c-src and c-Abl kinase inhibitor with ED50 of 25 nM, 4.2, 0.4, 1.3 and 1.7μM, respectively. NVP-BHG712 inhibits multiple E...
   918505-84-7 PLX 4720  more...
   Biological Activity of PLX-4720: PLX4720, a 7-azaindole derivative that inhibits B-RafV600E with an IC50 of 13 nM, defines a class of kinase inhibitor with marked selectivity in ...
   405554-55-4 SB590885  more...
   SB-590885 stabilizes the oncogenic B-Raf kinase domain in an active configuration, which is distinct from the previously reported mechanism of action of the multi-kinase inhibitor, BAY4...
   475207-59-1 Sorafenib tosylate  more...
   Sorafenib tosylate is the first listing of approved drugs targeting multiple targets, but also over the past decade is the only FDA approved drug for the treatment of renal cell carcino...
   1029872-54-5 Vemurafenib (PLX4032)  more...
   PLX4032 is a highly selective inhibitor of BRAF kinase activity, with an IC50 of 44 nmol/L against V600E-mutant BRAF. [1] BRAFV600E cancer-causing mutation occurs in most melanomas and ...
   208260-29-1 ZM 336372  more...
   ZM 336372 shows 10-fold selectivity over B-Raf. ZM 336372 weakly inhibits SAPK2a/p38α and SAPK2b/p38β with IC50 of 2 μM, and is selective over 17 other protein kinases including PKA, PK...

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