Product :
Prostaglandin D2
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Chemical Information
| Product name：Prostaglandin D2 |
Purity：≥98% HPLC |
| CAS NO：41598-07-6 |
Solubility： |
| Molecular Formula：C20H32O5 |
Package：Package according to customer requirements |
| Molecular Weight：352.5 |
Storage：-20°C, under argon/nitrogen, protected from light, sealed and dry; |
Remarks
Prostaglandin D2 (PGD2) is one of the major prostaglandins produced from arachidonic acid via the cyclooxygenase (COX) pathway. It is produced by mast cells, alveolar macrophages, Th2 cells, dendritic cells, and other cell types, and plays widespread roles in the central nervous system, the immune system, and allergic reactions.
References
Onoe H, Ueno R, Fujita I, Nishino H, Oomura Y, Hayaishi O. “Prostaglandin D2, a cerebral sleep-inducing substance in monkeys.” Proc Natl Acad Sci U S A. 1988;85(11):4082-4086. DOI: 10.1073/pnas.85.11.4082. PMCID: PMC280366.
Shimizu T, Mizuno N, Amano T, Hayaishi O. “Prostaglandin D2, a neuromodulator.” Proc Natl Acad Sci U S A. 1979 Dec;76(12):6231-6234. DOI: 10.1073/pnas.76.12.6231. PMCID: PMC411837. PMID: 230503.
Murray JJ, Tonnel AB, Brash AR, Roberts LJ II, Gosset P, Workman R, Capron A, Oates JA. “Release of Prostaglandin D2 into Human Airways during Acute Antigen Challenge.” N Engl J Med. 1986;315(13):800-804. DOI: 10.1056/NEJM198609253151304.
Trivedi SG, Newson J, Rajakariar R, et al. “Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity.” Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5179-5184. DOI: 10.1073/pnas.0507175103.