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CRT5 (CRT0066051), a pyrazine benzamide, is a potent and selective PKD inhibitor with IC50 of 1 nM, 2 nM, and 1.5 nM for PKD1, PKD2, and PKD3, respectively. CRT5 decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis.
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