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PF-00299804 Dacomitinib

PF-00299804 Dacomitinib 1042385-75-0
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Chemical Information
Product name:PF-00299804 Dacomitinib Purity:98% min
CAS NO:1042385-75-0 Solubility:DMSO : 50 mg/mL (106.40 mM)
Molecular Formula:C24H27ClFN5O3 Package:Package according to customer requirements
Molecular Weight:487.954 Storage:Store at -20℃
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Dacomitinib, aslo known as PF-299 and PF-00299804 ; or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types.
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