Pramipexole Dihydrochloride

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Chemical Information

Product name：Pramipexole Dihydrochloride	Purity：99% min
CAS NO：104632-25-9	Solubility：H2O : ≥ 50 mg/mL (175.90 mM)
Molecular Formula：C₁₀H₁₉Cl₂N₃S	Package：Package according to customer requirements
Molecular Weight：284.249	Storage：Store at -20℃

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Remarks

Pramipexole Dihydrochloride is an agonist of the Gαi-linked dopamine receptors D2, D3, and D4. It is relatively inactive at the Gαs-linked dopamine receptors D1 and D5, as well as at serotonin and adrenergic receptors. This narrow profile of receptor binding distinguishes pramipexole from other compounds, particularly those derived from ergot fungi, which can be associated with adverse events when used for treating Parkinson's disease and other disorders.

Properties:
Appearance & Physical State: white crystalline powder
Melting Point: 288-290ºC
Boiling Point: 378ºC at 760 mmHg
Flash Point: 182.4ºC
Vapor Pressure: 6.49E-06mmHg at 25°C

References

[1]. Mierau J, Schneider FJ, Ensinger HA et al. Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol. 1995 Jun 23;290(1):29-36.

[2]. El-Mallakh RS, Penagaluri P, Kantamneni A et al. Long-term use of pramipexole in bipolar depression: a naturalistic retrospective chart review. Psychiatr Q. 2010 Sep;81(3):207-13.