Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.
Properties:
Appearance & Physical State: White or off-white crystalline powder
Density: 1.19 g/cm3
Boiling Point: 871.7ºC at 760 mmHg
Melting Point: 113-115ºC
Flash Point: 481ºC
Refractive Index: 1.549
Storage Condition: -20ºC
Vapor Pressure: 1.73E-35mmHg at 25°C
Related Products:
Everolimus; Temsirolimus; PI-103; Torin 1; PF-04691502; Apitolisib; Torin 2; BGT226; Palomid 529; Deforolimus; KU-0063794; Rapamycin; Tacrolimus monohydrate