AST1306 tosilate

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Chemical Information

Product name：AST1306 tosilate	Purity：98% min
CAS NO：1050500-29-2	Solubility：DMSO : 50 mg/mL (80.50 mM)
Molecular Formula：C₃₁H₂₆ClFN₄O₅S	Package：Package according to customer requirements
Molecular Weight：621.078	Storage：Store at -20℃

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Remarks

AST-1306 TsOH is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.

References

[1]. Xie H, Lin L, Tong L et al. AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. PLoS One. 2011;6(7):e21487.