LP-211

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Chemical Information

Product name：LP-211	Purity：98% min
CAS NO：1052147-86-0	Solubility：DMSO : ≥ 106.6 mg/mL (228.45 mM)
Molecular Formula：C₃₀H₃₄N₄O	Package：Package according to customer requirements
Molecular Weight：466.63	Storage：Store at 2-8°C

Quality control

Remarks

LP-211 (10 mg/kg, i.p.) rapidly reaches the systemic circulation in the mouse, with mean C_max of 0.76 ± 0.32 μg/mL at 30 min. LP-211 (0.003-0.3 mg/kg, i.p.) significantly increases the micturition volume in a dose-dependent manner, and causes significant increases in voiding efficiency in spinal cord-injured (SCI) rats, and such effects can be completely reversed by SB-269970. LP-211 (0.25 and 0.50 mg/kg i.p.) improves consolidation of chamber-shape memory in rats, resulting in significant novelty-induced hyperactivity and recognition.

References

[1]. Leopoldo M, et al. Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. J Med Chem. 2008 Sep 25;51(18):5813-22.

[2]. Norouzi-Javidan A, et al. Effect of 5-HT7 receptor agonist, LP-211, on micturition following spinal cord injury in male rats. Am J Transl Res. 2016 Jun 15;8(6):2525-33. eCollection 2016.