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GSK-923295

GSK-923295 1088965-37-0
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Chemical Information
Product name:GSK-923295 Purity:98.0% min
CAS NO:1088965-37-0 Solubility:DMSO : 30 mg/mL (50.66 mM; Need ultrasonic)
Molecular Formula:C32H38ClN5O4 Package:Package according to customer requirements.
Molecular Weight:592.128 Storage:-20℃
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Remarks

GSK-923295, also known as GSK-923295A, is a novel antimitotic inhibitor of centromere-associated protein E (CENP-E) with potential anticancer activity. GSK923295A demonstrated significant antitumor activity against solid tumor models, inducing CRs in Ewing sarcoma, rhabdoid, and rhabdomyosarcoma xenografts. Clinical study showed that GSK923295 had dose-proportional pharmacokinetics and a low number of grade 3 or 4 adverse events. The observed incidence of myelosuppression and neuropathy was low. Further investigations may provide a more complete understanding of the potential for GSK923295 as an antiproliferative agent.

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