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Product :

Torkinib

Torkinib  1092351-67-1
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Chemical Information
Product name:Torkinib Purity:98% min
CAS NO:1092351-67-1 Solubility:10 mM in DMSO
Molecular Formula:C16H16N6O Package:Package according to customer requirements
Molecular Weight:308.338 Storage:Store at -20℃
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Remarks
Torkinib, also known as PP242 is a selective mTOR inhibitor with IC50 of 8 nM. PP242 suppresses bladder cancer cell proliferation and migration through deactivating the mammalian target of rapamycin complex 2/AKT1 signaling pathway. PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model. PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway. PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment.
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