Product :
ASP3026
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Chemical Information
| Product name：ASP3026 |
Purity：98% min |
| CAS NO：1097917-15-1 |
Solubility：DMSO : 20 mg/mL (34.44 mM) |
| Molecular Formula：C29H40N8O3S |
Package：Package according to customer requirements |
| Molecular Weight：580.745 |
Storage：Store at -20℃ |
Remarks
ASP3026 is a novel and selective inhibitor for the ALK kinase. ASP3026 potently inhibited ALK kinase activity and was more selective than crizotinib in a Tyr-kinase panel. In an anchorage independent in vitro cell growth assay, ASP3026 inhibited the growth of NCI-H2228, a human NSCLC tumor cell line endogenously expressing EML4-ALK variant 3 and that of 3T3 cells expressing EML4-ALK variant 1, 2 and 3. The plasma and tumor concentrations of ASP3026 in mice xenografted with NCI-H2228 tumor were determined using high-performance liquid chromatography-tandem mass spectrometry. Significant tumor penetration was observed.
References
[1] Sadao Kuromitsu, et al. AACR 102nd Annual Meeting, 2011.