GS-9451 Vedroprevir

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Chemical Information

Product name：GS-9451 Vedroprevir	Purity：98% min
CAS NO：1098189-15-1	Solubility：
Molecular Formula：C₄₅H₆₀ClN₇O₉S	Package：Package according to customer requirements
Molecular Weight：910.517	Storage：Store at -20℃

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Remarks

Vedroprevir, also known as GS9451, is a selective hepatitis C virus (HCV) NS3 protease inhibitor in development for the treatment of genotype 1 (GT1) HCV infection. GS-9451 was less active in GT2a replicon cells (EC50 = 316 nM). GS-9451 retained wild-type activity against multiple classes of NS5B and NS5A inhibitor resistance mutations. GS-9451 showed good oral bioavailability in all three species tested.

References

1: Meissner EG, Kohli A, Virtaneva K, Sturdevant D, Martens C, Porcella SF, McHutchison JG, Masur H, Kottilil S. Achieving sustained virologic response after interferon-free hepatitis C virus treatment correlates with hepatic interferon gene expression changes independent of cirrhosis. J Viral Hepat. 2016 Feb 3. doi: 10.1111/jvh.12510. [Epub ahead of print] PubMed PMID: 26840694.

2: Petersen T, Townsend K, Gordon LA, Sidharthan S, Silk R, Nelson A, Gross C, Calderón M, Proschan M, Osinusi A, Polis MA, Masur H, Kottilil S, Kohli A. High adherence to all-oral directly acting antiviral HCV therapy among an inner-city patient population in a phase 2a study. Hepatol Int. 2016 Mar;10(2):310-9. doi: 10.1007/s12072-015-9680-7. Epub 2015 Nov 26. PubMed PMID: 26612014; PubMed Central PMCID: PMC4778154.