Endoxifen

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Chemical Information

Product name：Endoxifen	Purity：98% min
CAS NO：110025-28-0	Solubility：10 mM in DMSO
Molecular Formula：C₂₅H₂₇NO₂	Package：Package according to customer requirements
Molecular Weight：373.487	Storage：Store at -20℃

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Remarks

Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity.

Properties:
Density: 1.099g/cm3
Boiling Point: 519.3ºC at 760mmHg
Flash Point: 267.9ºC
Refractive Index: 1.598
Vapor Pressure: 2.1E-11mmHg at 25°C

References

[1]. Goetz MP, et al. Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. Oncology (Williston Park). 2009 Dec;23(14):1233-4, 1236.

[2]. Wu X, et al. The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res. 2009 Mar 1;69(5):1722-7.