E-2020 Donepezil HCl

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Chemical Information

Product name：E-2020 Donepezil HCl	Purity：98% min
CAS NO：110119-84-1	Solubility：DMSO : 6.2 mg/mL (14.91 mM)
Molecular Formula：C₂₄H₃₀ClNO₃	Package：Package according to customer requirements
Molecular Weight：415.953	Storage：Store at -20℃

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Remarks

Donepezil HCl is a GSK3 and AChE inhibitor and potential σ1 receptor agonist used to treat Alzheimer's disease. It also improves learning and memory, downregulates expression of NR1 subuinit of NMDA receptors, decreases left ventricular end diastolic pressure, and increases left ventricular contractility.

References

[1]. Dubois B, et al. Donepezil in Parkinson's disease dementia: A randomized, double-blind efficacy and safety study. Mov Disord. 2012 Sep 1;27(10):1230-8.

[2]. Zaidel L, et al. Donepezil effects on hippocampal and prefrontal functional connectivity in Alzheimer's disease: preliminary report. J Alzheimers Dis. 2012 Jan 1;31(0):S221-6.

[3]. Tsuno N. Donepezil in the treatment of patients with Alzheimer's disease. Expert Rev Neurother. 2009 May;9(5):591-8.