JZL184

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Chemical Information

Product name：JZL184	Purity：98% min
CAS NO：1101854-58-3	Solubility：DMSO : ≥ 35 mg/mL (67.24 mM)
Molecular Formula：C₂₇H₂₄N₂O₉	Package：Package according to customer requirements
Molecular Weight：520.487	Storage：Store at -20℃

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Remarks

JZL184 is highly selective, and potent MAGL inhibitor ( monoacylglycerol lipase inhibitor). JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome. JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. JZL184 also suppresses inflammatory pain in the mouse carrageenan model.

Properties:
Density: 1.467 g/cm3
Boiling Point: 706.4ºC at 760 mmHg
Flash Point: 381ºC

Lipase Inhibitors Related Products:

Atglistatin; XEN445; Orlistat

References

[1]. Long JZ, et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol. 2009 Jan;5(1):37-44.

[2]. Pan B, et al. Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. J Pharmacol Exp Ther. 2009 Nov;331(2):591-7.