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IWR-1 1127442-82-3
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Chemical Information
Product name:IWR-1 Purity:98% min
CAS NO:1127442-82-3 Solubility:DMSO : ≥ 46 mg/mL (112.35 mM)
Molecular Formula:C25H19N3O3 Package:Package according to customer requirements
Molecular Weight:409.437 Storage:Store at -20℃
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IWR-1, also known as IWR-1-endo, is a an inhibitor of the Wnt signaling cascade through inhibiting TNKSs, binding only to the adenosine-binding site. IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression. IWR-1 inhibits cell proliferation and EMT even in the presence of TNF-α-induced cancer cell stimulation. IWR-1 also significantly suppressed cell migration, invasion, and matrix metalloproteinase activities of CRC cell lines. IWR-1 provides EMT reversal effects by directly suppressing survivin expression.
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