Trabectedin

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Chemical Information

Product name：Trabectedin	Purity：98% min
CAS NO：114899-77-3	Solubility：DMSO : 33.33 mg/mL (43.75 mM)
Molecular Formula：C₃₉H₄₃N₃O₁₁S	Package：Package according to customer requirements.
Molecular Weight：761.837	Storage：Store at -20 ℃

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Remarks

Trabectedin (Ecteinascidin 743; ET-743) a tetrahydroisoquinoline alkaloid with potent antitumor activity isolated from Ecteinascidia turbinata. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment.

Chemical Properties:

alpha: D25 +114° (c = 0.1 in methanol)

density: 1.55±0.1 g/cm3 (20 ºC 760 Torr)

pka: 9.73±0.40(Predicted)

Related Products:

Trabectedin intermediate(1218781-83-9; 2291328-13-5; 442663-63-0; 366020-68-0; 308359-33-3; 265134-87-0; 2291328-15-7; 236743-98-9)

References

[1]. Takahashi N, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell linesin vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15.

[2]. Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Jun 20;221(2):128-136.