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Docetaxel

Docetaxel 114977-28-5
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Chemical Information
Product name:Docetaxel Purity:98% min
CAS NO:114977-28-5 Solubility:DMSO: ≥ 35 mg/mL
Molecular Formula:C43H53NO14 Package:Packaging according to customer requirements
Molecular Weight:807.8 Storage:Store at -20℃
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Remarks
Docetaxel (DOC) and Glufosfamide (GLU) single and combined treatments affect the cells viability in a dose-dependent manner. The IC50 of GLU are 70±4 µM and 86.8±8 µM in PC-3 and LNCaP cells; respectively. While, the IC50 of Docetaxel alone is found to be 3.08±0.4 nM and 1.46±0.2 nM in PC-3 and LNCaP cells; respectively. The co-treatment of GLU with Docetaxel is found to synergize the cytotoxicity and the IC50 values are decreased to be 2.7±0.1 nM and 0.75±0.3 nM in PC-3 and LNCaP cells; respectively. IC50 of NCI-H460 to Docetaxel at 24 h is 116 nM and at 72 h is 30 nM. According to data reported in DTP Data Search, the mean IC50 of NCI-60 cell panel to Docetaxel is 14-34 nM.
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