MK-571 sodium salt

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Chemical Information

Product name：MK-571 sodium salt	Purity：98% min
CAS NO：115103-85-0	Solubility：DMSO : ≥ 33 mg/mL (61.44 mM)
Molecular Formula：C₂₆H₂₆ClN₂NaO₃S₂	Package：Package according to customer requirements
Molecular Weight：537.069	Storage：Store at -20℃

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Remarks

MK-571 is a selective, orally active CysLT1 receptor antagonist. It blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively. MK-571 attenuates kidney ischemia and reperfusion-induced airway hypersensitivity in rats. MK-571 alters bronchoalveolar lavage fluid proteome in a mouse asthma model.

References

[1]. Jones TR, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D₄ receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28.

[2]. Hara Y, et al. Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice. J Clin Invest. 2011 Jul;121(7):2888-97.