ML-128 VU 0361737

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Chemical Information

Product name：ML-128 VU 0361737	Purity：98% min
CAS NO：1161205-04-4	Solubility：DMSO : ≥ 43 mg/mL (163.69 mM)
Molecular Formula：C₁₃H₁₁ClN₂O₂	Package：Package according to customer requirements
Molecular Weight：262.692	Storage：Store at -20℃

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Remarks

VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors.

References

[1]. Jantas D, et al. Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state. Neuropharmacology. 2014 Aug;83:36-53

[2]. Jantas D, et al. Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation. Neurochem Int. 2015 Sep;88:124