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Gs-441524

Gs-441524 1191237-69-0
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Chemical Information
Product name:Gs-441524 Purity:98% min
CAS NO:1191237-69-0 Solubility:
Molecular Formula:C12H13N5O4 Package:Package according to customer requirements
Molecular Weight:291.26 Storage:
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Remarks
GS-441524 is an adenosine nucleotide analog antiviral, similar to [remdesivir]. This molecule was patented in 2009. In vitro studies of GS-441524 have determined it has a higher EC50 than remdesivir against a number of viruses, meaning GS-441524 is less potent. GS-441524 continues to be studied in the treatment of Feline Infectious Peritonitis Virus, a coronavirus that only infects cats.
References

Impact of remdesivir modifications on human HINT1 binding – A structural and functional study in the remdesivir activation pathway;Publication Name: Structure (London, England : 1993);Publication Date: 2026-05-25;PMID: 42184828;DOI: 10.1016/j.str.2026.04.015

Efectividad y seguridad de remdesivir y nirmatrelvir-ritonavir en la COVID-19 leve-moderada en los servicios de urgencia hospitalaria españoles;Publication Name: Medicina Clínica;Publication Date: 2025-08;PMID: 40412101;DOI: 10.1016/j.medcli.2025.106912

Successful treatment of prolonged COVID-19 with remdesivir and nirmatrelvir/ritonavir in a patient with a history of diffuse large B-cell lymphoma: a case report;Publication Name: Journal of the Egyptian National Cancer Institute;Publication Date: 2025-06-30;PMID: 40583098;DOI: 10.1186/s43046-025-00291-1

Eco-friendly spectrofluorimetric determination of remdesivir in the presence of its metabolite in human plasma for therapeutic monitoring in COVID-19 patients;Publication Name: Scientific Reports;Publication Date: 2025-06-23;PMID: 40550830;DOI: 10.1038/s41598-025-05198-4

Pharmacokinetics and Metabolism of Broad-Spectrum Antivirals Remdesivir and Obeldesivir with a Consideration to Metabolite GS-441524: Same, Similar, or Different?;Publication Name: Viruses;Publication Date: 2025-06-10;PMID: 40573427;DOI: 10.3390/v17060836

Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19;Publication Name: Clinical Pharmacokinetics;Publication Date: 2025-04-22;PMID: 40261493;DOI: 10.1007/s40262-025-01496-2

High‐dose induction therapy and treatment termination criteria for feline infectious peritonitis with remdesivir, GS‐441524 and adjunctive mefloquine: 46 cases (2023);Publication Name: The Journal of small animal practice;Publication Date: 2025-04-18;PMID: 40251466;DOI: 10.1111/jsap.13869

Treatment of feline infectious peritonitis in cats with molnupiravir: clinical observations and outcomes for 54 cases;Publication Name: Australian Veterinary Journal;Publication Date: 2025-04-15;PMID: 40234239;DOI: 10.1111/avj.13433

Pharmacokinetics of GS‐441524 following intravenous remdesivir in six cats and results of therapeutic drug monitoring during treatment of feline infectious peritonitis: 22 cases (2021–2024);Publication Name: The Journal of small animal practice;Publication Date: 2025-03-17;PMID: 40097914;DOI: 10.1111/jsap.13849

Remdesivir is active in vitro against tick-borne encephalitis virus and selects for resistance mutations in the viral RNA-dependent RNA polymerase;Publication Name: Infectious diseases (London, England);Publication Date: 2025-02-20;PMID: 39973341;DOI: 10.1080/23744235.2025.2468510

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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