NITD609 Cipargamin

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Chemical Information

Product name：NITD609 Cipargamin	Purity：98% min
CAS NO：1193314-23-6	Solubility：DMSO : ≥ 150 mg/mL (384.38 mM)
Molecular Formula：C₁₉H₁₄Cl₂FN₃O	Package：Package according to customer requirements
Molecular Weight：390.238	Storage：Store at -20℃

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Remarks

Cipargamin, also known as NITD609, GNF-609 and KAE609, is a potent Spiroindolone inhibitor of Plasmodium falciparum growth with potent, dose-dependent antimalarial activity against asexual and sexual stages of Plasmodium. NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector.

References

[1]. Zhou Y, et al. Spiroindolone that inhibits PfATPase4 is a potent, cidal inhibitor of Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2014;58(3):1789-92.

[2]. van Pelt-Koops JC, et al. The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector. Antimicrob Agents Chemother. 2012 Jul;56(7):3544-8.

[3]. Rottmann M, et al. Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010 Sep 3;329(5996):1175-80.