CX-6258

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Chemical Information

Product name：CX-6258	Purity：98% min
CAS NO：1202916-90-2	Solubility：DMSO : ≥ 50 mg/mL (108.24 mM)
Molecular Formula：C₂₆H₂₄ClN₃O₃	Package：Package according to customer requirements
Molecular Weight：461.94	Storage：Store at -20℃

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Remarks

CX-6258 is a pan-Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. CX-6258 exhibited in vitro synergy with chemotherapeutics and robust in vivo efficacy in two Pim kinases driven tumor models. Inhibition of Pim kinases is expected to have a beneficial effect as cancer therapy.

References

[1]. Mustapha Haddach, Jerome Michaux, Michael K, Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med. Chem. Lett., 2012, 3 (2), pp 135-139

[2]. Padmanabhan A, Gosc EB, Bieberich CJ. Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells. J Cell Biochem. 2013 May;114(5):1050-7.