Alendronate sodium hydrate

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Chemical Information

Product name：Alendronate sodium hydrate	Purity：98% min
CAS NO：121268-17-5	Solubility：Soluble in DMSO
Molecular Formula：C₄H₁₈NNaO₁₀P₂	Package：Package according to customer requirements
Molecular Weight：325.124	Storage：Store at -20℃

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Remarks

Alendronic acid (INN) or alendronate sodium (USAN) - sold as Fosamax by Merck - is a bisphosphonate drug used for osteoporosis, osteogenesis imperfecta, and several other bone diseases. It is marketed alone as well as in combination with vitamin D (2,800 IU and 5,600 IU, under the name Fosamax+D). Merck's U.S. patent on alendronate expired in 2008 and the drug is now available as a generic. This is the most widely prescribed bisphosphonate medicine in the United States .

Properties
Appearance & Physical State: White Crystalline Solid
Density: 1.857g/cm3
Melting Point: 245ºC
Boiling Point: 616.7ºC at 760 mmHg
Flash Point: 326.7ºC
Storage Condition: -20ºC

References

[1]. Fisher JE, et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8.

[2]. Bergstrom JD, et al. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000 Jan 1;373(1):231-41.