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GKT137831  1218942-37-0
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Chemical Information
Product name:GKT137831 Purity:98% min
CAS NO:1218942-37-0 Solubility:DMSO : ≥ 37 mg/mL (93.71 mM)
Molecular Formula:C21H19ClN4O2 Package:Package according to customer requirements
Molecular Weight:394.854 Storage:Store at -20℃
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GKT137831, also known as GTK831, is a novel and potent Nox4 inhibitor. GKT137831 reduced the increased leukocyte adherence to the vasculature, the pro-inflammatory phenotype of microglia and macroglia, the increased gene and protein expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and leukocyte adhesion molecules as well as vascular leakage. In all cultured cell types, GKT137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators. GKT137831 may be potentially useful as a treatment for a variety of vision-threatening retinopathies.
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