Product :
AVN-492
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Chemical Information
| Product name：AVN-492 |
Purity：98% min |
| CAS NO：1220646-23-0 |
Solubility：DMSO : ≥ 100 mg/mL (278.20 mM) |
| Molecular Formula：C17H21N5O2S |
Package：Package according to customer requirements |
| Molecular Weight：359.446 |
Storage：Store at -20℃ |
Remarks
AVN-492 is a potent and selective 5-HT6R Antagonist. The affinity of AVN-492 to bind to 5-HT6R (Ki = 91 pM) was more than three orders of magnitude higher than that to bind to the only other target, 5-HT2BR, (Ki = 170 nM). AVN-492 demonstrates good in vitro and in vivo ADME profile with high oral bioavailability and good brain permeability in rodents.