GS-9620 Vesatolimod

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Chemical Information

Product name：GS-9620 Vesatolimod	Purity：98% min
CAS NO：1228585-88-3	Solubility：DMSO : 4.8 mg/mL (11.69 mM)
Molecular Formula：C₂₂H₃₀N₆O₂	Package：Package according to customer requirements
Molecular Weight：410.513	Storage：Store at -20℃

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Remarks

Vesatolimod, also known as GS-9620, is a potent and oral agonist of Toll-like receptor-7 developed for finite treatment of chronic hepatitis B viral (HBV) infection, with the goal of inducing a liver-targeted antiviral effect without inducing the adverse effects associated with current systemic interferon-α (IFN-α) therapies. GS-9620 demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses. GS-9620 can induce a sustained antiviral response in the woodchuck model of CHB.

References

[1]. Rebbapragada I, et al. Molecular Determinants of GS-9620-Dependent TLR7 Activation. PLoS One. 2016 Jan 19;11(1):e0146835.

[2]. Lanford RE, et al. GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees. Gastroenterology. 2013 Feb 13. pii: S0016-5085(13)00169-8.