Doxepin hydrochloride

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Chemical Information

Product name：Doxepin hydrochloride	Purity：98% min
CAS NO：1229-29-4	Solubility：DMSO : ≥ 100 mg/mL (316.62 mM)
Molecular Formula：C₁₉H₂₂ClNO	Package：Package according to customer requirements
Molecular Weight：315.837	Storage：Store at 2-8°C

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Remarks

Doxepin hydrochloride is a highly potent Histamine H1 Receptor (histamine H1) antagonist. Doxepin hydrochloride also binds to histamine H4 receptor. Doxepin hydrochloride is an inhibitor of AR and mAChR. Doxepin Hydrochloride is a dibenzoxepin derivative and tricyclic antidepressant with antipruritic and sedative activities. Doxepin also has antagonistic effects on histamine (H1 and H2), 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is the result mediated through inhibition of histamine receptors.

Properties:
Appearance & Physical State: white to off-white powder
Boiling Point: 413.3ºC at 760mmHg
Flash Point: 121.3ºC
Vapor Pressure: 4.87E-07mmHg at 25°C

References

[1] Hajak G, et al. J Clin Psychiatry, 2001, 62(6), 453-463.

[2] Shimamura T, et al. Nature, 2011, 475(7354), 65-70.

[3] McCleane G, Br J Clin Pharmacol, 2000, 49(6), 574-579.