GSK2251052 Epetraborole hydrochloride

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Chemical Information

Product name：GSK2251052 Epetraborole hydrochloride	Purity：98% min
CAS NO：1234563-16-6	Solubility：Soluble in DMSO
Molecular Formula：C₁₁H₁₇BClNO₄	Package：Package according to customer requirements
Molecular Weight：273.521	Storage：Store at -20℃

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Remarks

Epetraborole hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor, which inhibits protein synthesis by binding "to the terminal adenosine ribose (A76) of leucyl-tRNA synthetase".

References

[1]. Goldstein EJ et al. Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms. Antimicrob Agents Chemother. 2013 May;57(5):2401-4.

[2]. O'Dwyer K et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment ofcomplicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98.