SAR191801 hPGDS-IN-1

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Chemical Information

Product name：SAR191801 hPGDS-IN-1	Purity：98% min
CAS NO：1234708-04-3	Solubility：DMSO : ≥ 30 mg/mL (72.04 mM)
Molecular Formula：C₂₂H₂₀N₆O₃	Package：Package according to customer requirements
Molecular Weight：416.433	Storage：Store at -20℃

Quality control

Remarks

hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay. IC50 value: 12 nM Target: hPGDS The detailed information please refer to WO2011044307A1 and WO2010080563A2

References

[1]. Vandeusen, Christopher L, et al. Phenyloxadiazole derivatives as PGD inhibitors and their preparation, pharmaceutical compositions and use in the treatment of allergic and inflammatory disorders. From PCT Int. Appl. (2011), WO 2011044307 A1 20110414.

[2]. Hahn Chang S. Method for treating macular degeneration using syk multikinase inhibitor, an hPGDS inhibitor and a DP antagonist. From PCT Int. Appl. (2010), WO 2010080563 A2 20100715.