P7C3-A20

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Chemical Information

Product name：P7C3-A20	Purity：98% min
CAS NO：1235481-90-9	Solubility：DMSO : ≥ 100 mg/mL (197.55 mM)
Molecular Formula：C₂₂H₁₉Br₂FN₂O	Package：Package according to customer requirements.
Molecular Weight：506.205	Storage：Store at -20℃

Quality control

COA

Remarks

P7C3-A20 is an analogue of P7C3, and is a proneurogenic, neuroprotective agent. P7C3-A20 displayed increased activity and an improved toxicity profile compared to P7C3. P7C3-A20 demonstrated greater proneurogenic efficacy than a wide spectrum of currently marketed antidepressant drugs. P7C3-A20 showed neuroprotective properties in rodent models of Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury and age-related cognitive decline.

References

[1]. Blaya MO et al. Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury. J Neurotrauma. 2014 Mar 1;31(5):476-86.

[2]. Walker AK et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasinghippocampal neurogenesis. Mol Psychiatry. 2015 Apr;20(4):500-8.