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Remarks
EXP-3174, also known as Losartan Carboxylic Acid, is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. Like the parent compound, EXP-3174 is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability.
Properties:
Appearance & Physical State: Light-Yellow Solid
Density: 1.41g/cm3
Melting Point: 130-132ºC
Boiling Point: 707.8ºC at 760mmHg
Flash Point: 381.8ºC
Refractive Index: 1.695
Vapor Pressure: 5.04E-21mmHg at 25°C