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SP-141

SP-141 1253491-42-7
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Chemical Information
Product name：SP-141 Purity：98% min
CAS NO：1253491-42-7 Solubility：
Molecular Formula：C22H16N2O Package：Package according to customer requirements.
Molecular Weight：324.375 Storage：-20 ℃
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Remarks

SP-141 is a specific inhibitor of MDM2. SP-141 promotes MDM2 auto-ubiquitination and degradation. SP-141 might be used for the research of pancreatic cancer and breast cancer cells.

References

[1]. Wei Wang , et al. Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice. Gastroenterology. 2014 Oct;147(4):893-902.e2.

[2]. Wei Wang, et al. The Pyrido[b]indole MDM2 Inhibitor SP-141 Exerts Potent Therapeutic Effects in Breast Cancer Models. Nat Commun. 2014 Oct 1;5:5086.

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