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CH5424802 Alectinib

CH5424802 Alectinib 1256580-46-7
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Chemical Information
Product name:CH5424802 Alectinib Purity:98% min
CAS NO:1256580-46-7 Solubility:10 mM in DMSO
Molecular Formula:C30H34N4O2 Package:Package according to customer requirements
Molecular Weight:482.617 Storage:Store at -20℃
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Remarks
Alectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. CH5424802 inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth. Alectinib was approved in Dec. 2015.
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