Product :
LY 2886721 hydrochloride salt
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Chemical Information
| Product name：LY 2886721 hydrochloride salt |
Purity：98% min |
| CAS NO：1262036-49-6 |
Solubility：Soluble in DMSO |
| Molecular Formula：C18H17ClF2N4O2S |
Package：Package according to customer requirements |
| Molecular Weight：426.868 |
Storage：Store at -20℃ |
Remarks
LY2886721 is a potent and selective BACE1 inhibitor. LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans. LY2886721 has high selectivity against key off-target proteases, which efficiently translates in vitro activity into robust in vivo amyloid β lowering in nonclinical animal models. Similar potent and persistent amyloid β lowering was observed in plasma and lumbar CSF when single and multiple doses of LY2886721 were administered to healthy human subjects. BACE1 is a key protease controlling the formation of amyloid β, a peptide hypothesized to play a significant role in the pathogenesis of Alzheimer's disease (AD).