VTP-27999 Hydrochloride

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Chemical Information

Product name：VTP-27999 Hydrochloride	Purity：99.0% min
CAS NO：1264191-73-2	Solubility：H2O : ≥ 100 mg/mL (178.08 mM)
Molecular Formula：C₂₆H₄₂Cl₂N₄O₅	Package：Package according to customer requirements
Molecular Weight：561.541	Storage：Store at -20℃

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Remarks

VTP-27999 is a highly potent and selective renin inhibitor (IC50 = 0.47 nM). VTP-27999 demonstrated excellent selectivity over related and unrelated off-targets, >15% oral bioavailability in three species, oral efficacy in a double transgenic rat model of hypertension, and good exposure in humans.

VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.

References

[1]. Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751

[2]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082.