Verubecestat MK-8931

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Chemical Information

Product name：Verubecestat MK-8931	Purity：99% min
CAS NO：1286770-55-5	Solubility：Soluble in DMSO
Molecular Formula：C₁₇H₁₇F₂N₅O₃S	Package：Packaging according to customer requirements
Molecular Weight：409.41	Storage：Store at -20℃

Quality control

Remarks

MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase. target: BACE1. In vitro:MK-8931 can effectively reduce Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM. [1] Docking revealed that, with respect to their free binding energy, acylguanidine 7a has the lowest binding energy followed by MK-8931 and pioglitazone and binds significantly to β-secretase. [2]

References

[1]. Yan R Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs. Transl Neurodegener. 2016 Jul 14;5:13.

[2]. Nisha CM et al. Molecular Docking and In Silico ADMET Study Reveals Acylguanidine 7a as a Potential Inhibitor of β-Secretase. Adv Bioinformatics. 2016 Apr 10.