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Verubecestat (MK-8931)

Verubecestat (MK-8931) 1286770-55-5
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Chemical Information
Product name:Verubecestat (MK-8931) Purity:99% min
CAS NO:1286770-55-5 Solubility:Soluble in DMSO
Molecular Formula:C17H17F2N5O3S Package:Packaging according to customer requirements
Molecular Weight:409.41 Storage:Store at -20℃
Quality control
MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase. target: BACE1. In vitro:MK-8931 can effectively reduce Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM. [1] Docking revealed that, with respect to their free binding energy, acylguanidine 7a has the lowest binding energy followed by MK-8931 and pioglitazone and binds significantly to β-secretase. [2]
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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