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|Product name：Verubecestat (MK-8931)
||Solubility：Soluble in DMSO
||Package：Packaging according to customer requirements
||Storage：Store at -20℃
MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase. target: BACE1. In vitro:MK-8931 can effectively reduce Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM.  Docking revealed that, with respect to their free binding energy, acylguanidine 7a has the lowest binding energy followed by MK-8931 and pioglitazone and binds significantly to β-secretase.