lactacystin

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Chemical Information

Product name：lactacystin	Purity：98% min
CAS NO：133343-34-7	Solubility：
Molecular Formula：C₁₅H₂₄N₂O₇S	Package：Package according to customer requirements
Molecular Weight：376.425	Storage：Store at -20℃

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Remarks

Lactacystin is a proteasome inhibitor found in Streptomyces. It increases the Bax/Bcl-2 ratio and inhibits proliferation of glioma cells, inhibits growth and migration of smooth muscle cells, and suppresses infiltration of neutrophils and decreases levels of ICAM-1 in liver injury models.

References

1: Konieczny J, Czarnecka A, Kamińska K, Lenda T, Nowak P. Decreased behavioral response to intranigrally administered GABAA agonist muscimol in the lactacystin model of Parkinson's disease may result from partial lesion of nigral non-dopamine neurons: comparison to the classical neurotoxin 6-OHDA. Behav Brain Res. 2015 Apr 15;283:203-14. doi: 10.1016/j.bbr.2015.01.043. Epub 2015 Feb 2. PubMed PMID: 25655509.

2: Harrison IF, Crum WR, Vernon AC, Dexter DT. Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors. Br J Pharmacol. 2015 Aug;172(16):4200-15. doi: 10.1111/bph.13208. Epub 2015 Jul 8. PubMed PMID: 26040297; PubMed Central PMCID: PMC4543623.