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CUDC-907 fimepinostat

CUDC-907 fimepinostat 1339928-25-4
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Chemical Information
Product name:CUDC-907 fimepinostat Purity:98% min
CAS NO:1339928-25-4 Solubility:DMSO : ≥ 50 mg/mL (98.32 mM)
Molecular Formula:C23H24N8O4S Package:Package according to customer requirements
Molecular Weight:508.553 Storage:Store at -20℃
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CUDC-907, also known as fimepinostat, is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC.

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